The latest edition of the Journal of Immunology publishes Andre’s paper on regulation of macrophage CD4, and highlights it in the “In this Issue” section. Read the paper, “Protein Kinase C and NF-κB–Dependent CD4 Downregulation in Macrophages Induced by T Cell-Derived Soluble Factors: Consequences for HIV-1 Infection” at http://www.jimmunol.org/content/187/2/748.